SYNERGISTIC EFFECT OF THE WLBU2 ANTIMICROBIAL PEPTIDE IN COMBINATION WITH COMMON ANTIBIOTICS AGAINST CLINICAL ISOLATES OF MULTI-DRUG RESISTANCE PATHOGENIC BACTERIA
Ayat Khasawneh MD*, Deifallah Alsharari MD, Hayat Khasawneh MD, Mohammad Al-Khawaldeh MD and Zain Abu Sitteh M. T.
ABSTRACT
Antimicrobial resistance (AMR) is a global burden that negatively affect health care system and economy. Resistance pattern to traditional antibiotics increasing dramatically making these agents ineffective to treat infections caused by resistance pathogens. Recently, researches and studies are directed toward new therapeutic options including development of engineered cationic antimicrobial peptides such as WLBU2. In our study, Ceftriaxone, Ciprofloxacin and Ceftazidime in combined with WLBU2 were utilized against fifty clinical isolates of Proteus mirabilis (n=25) and Pseudomonas aeruginosa (n=25) to evaluate the activity and the effect of combination. The obtained results revealed that synergistic and additive effect were observed and achieved with significant ratio at low MIC and provide potent inhibitory and bactericidal effects.
Keywords: Antimicrobial Peptides (AMPs), Engineered cationic peptides WLBU2, Multidrug resistance, Proteus mirabilis, Pseudomonas aeruginosa, Synergistic effect.
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