European Journal of Biomedical and Pharmaceutical Sciences

28 DAYS REPEATED DOSE ORAL TOXICITY STUDY OF HYDROALCOHOLIC EXTACT OF SESBANIA SESBAN LEAVES IN EXPERIMENTAL RATS

Rutuja D. Vibhute*, Swati U. Kolhe and Sachin V. Tembhurne

ABSTRACT

Natural medication is the hotspot for the inquiry of numerous novel helpful mixes in agricultural nations. Prior to utilized as medication, drugs from plant cause must be guaranteed safe. The study is aimed at evaluating the possible toxicity in 28-day subacute oral toxicity of hydroalcoholic extract Sesbania sesban (S.sesban) in male and female Wistar rats. The 28-day subacute poisonousness study was directed to recognize the no-watched unfriendly impact level (NOAEL). In this investigation, a sum of 48 rodents were isolated into the control, low dose (200 mg/kg), medium dose (500 mg/kg) and high dose (1000 mg/kg) gatherings. The HAESS was given daily from day 1 until day 28. At the last day of the study, the animals were humanely sacrificed and assessed for the effect extract of Sesbania sesban leaves on body weight and relative organ weights and hematological, biochemical and histopathological parameters.

Keywords: subacute oral toxicity Sesbania sesban, biochemical analysis, hematological parameters, histopathology.