European Journal of Biomedical and Pharmaceutical Sciences

THE USE OF CHITOSAN TO FORMULATE IBUPROFEN GRANULES I: PHYSICO-CHEMICAL CHARACTERIZATION

*Fadia Mussa, Fathia Almani and Mahmud Treki

ABSTRACT

Granules of a combination of Chitosan and hydroxypropyl cellulose (HPC) were prepared by wet granulation method using 1% (w/v) lactic acid solution. The granules were physico-chemically characterized in terms of density, porosity, angle of repose, carr’s index and housner ratio and found to be free flowing with good compressibility. The observed results of content uniformity indicated that the drug was uniformly distributed throughout the four formulations. The angles repose for the formulations A1, A2 and A4 were found to be 24 1 ,23 7 and 23 31 , respectively, which are considered as very free flowing granules according to arr s classification of flow-ability. To investigate the possible interactions between the API and the polymers contained in formulations A1-A4, FTIR spectroscopy was used. In order to detect the possible spectral changes due to the polymer/ Ibuprofen interaction (if any) and due to the formulation process the resulting spectra were compared to that of standard Ibuprofen, where no important shift of the vibrational band of the carbonilic moiety (1708 cm-1) were occurred, and no important changes were recorded.

Keywords: Granules, Chitosan, hydroxyl propyl cellulose, Physico-chemical characterization.