CYP 3A5*3 GENE POLYMORPHISM AMONG SUDANESE PATIENTS WITH CHRONIC MYELOID LEUKEMIA
Elharam Ibrahim Abdallah, Nazik Ibrahim M. AIamin, Wala Eldin Osman Elradi, Salah Eldin G. Elzaki, Mohammed Mobarak Elbashei*, Adel Yousif Elmahi and Nassr Eldin Mohamed Ahmed Shrif
ABSTRACT
Introduction: Interaction of environmental and genetic elements plays a vital role in the pathogenesis of CML and other types of cancer. CYP 3A5 is enzyme responsible of metabolizing of approximately 50 % of therapeutic drugs and xenobiotics. So polymorphism variation may genetically predispose individuals to CML. Objective: The purpose of this study was to determine CYP3A5*3 Polymorphism among Sudanese patients with Chronic Myeloid Leukemia (CML). Materials and Methods: This case control study was conducted among 50 patients with chronic myeloid leukemia among both genders at different ages and 42 apparently healthy control subjects. The CYP3A5*3 genotype was determined using (PCR-RFLP) method. Results: Paerson`s chi-square test was used to assess the possible link between CYP3A5*3 genotype and CML. The percentage of CYP3A5*3*3 genotype in CML patients was significantly higher than in control (OR = 11.71, 95% CI: 4.30 –31.83; p =0.000). The frequency of mutant genotype was higher among CML patients with advance phase compared with chronic phase, 100% versus 80% respectively. Conclusion: CYP3A5*3/*3 genotype associated with CML development and progression.
Keywords: CML: Chronic Myeloid Leukemia, CYP3A5*3: polymorphism of the gene cytochrome P450.
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