European Journal of Biomedical and Pharmaceutical Sciences

GASTRO-RETENTIVE DRUG DELIVERY SYSTEM OF ANTIHYPERTENSIVE DRUG

Shashikant Chandrakar, Chandrakant Yadav*, Amit Roy, Pushpa P. Gupta, Riya Vaiswade, Ashish Verma, Akhilesh Kumar

ABSTRACT

The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to achieve promptly and then maintain the desired drug concentration. Oral administration has only limited use for important drugs from various pharmacological categories that have poor oral bio-availability due to incomplete absorption and/or degradation in the gastrointestinal tract (GIT). Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short half-life are eliminated quickly from the blood circulationso they require frequent dosing to avoid this drawback, the oral sustained-controlled release formulations have been developed in an attempt to release the drug slowly into the gastrointestinal tract (GIT) and maintain an effective drug concentration in the serum for longer period of time. Variousgastro retentive approaches have designed and developed until now, i.e. floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems. Finally, advantages of gastro retentive drug delivery systems were covered in detail.

Keywords: Gastro-retentive drug delivery system (GRDSs), mucoadhesive system, floating system, swelling, gastric emptying, bioavailability, antihypertensive drugs.