Abstract
THE IMPACT OF LEAD NITRATE ON LIVER OF RATS

Khalid H. Gathwan*

ABSTRACT

The present study is to evaluate the toxic effects of lead nitrate on the liver structure of male rats. Male rats wighting 60-165 g, 70 days old, were treated orally with 6-18 mg/kg (body wt.) lead nitrate. The body weight, liver weight, histological of liver. Lead induced increases in apoptotis and severity of necrosis in liver. Liver weight and body eight decreased with increasing doses. Histological changes in the liver included hepatocyte degeneration, nuclear pycnosis,cellular swelling, and congestion ofblood vessels.There was a marked difference in these changes among the different treatments of lead concentrations in addition to the intensity of histological changes which were, however, influenced by the extent of the exposure period. It has been concluded that lead caused apoptotis in liver of male rats.

Keywords: Lead, Liver, Necrosis.


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