“A PROSPECTIVE CASE SERIES TO CHECK THE CLINICAL EFFICACY OF UNANI MEDICINE IN INFLAMMATORY BOWEL DISEASE (IBD) – AANTON KI SOZISH”
Dr. Asma Sultana, Dr. Kamar Sultana, Dr. Uzma Viquar*, Dr. Iffat Naz
ABSTRACT
Inflammatory bowel disease (IBD) is the leading cause of chronic intestinal conditions in the world. Although great strides have been made in the diagnosis, treatment and pathology of IBD; much has yet to be explained. The etiologies and risk factors of this multifactorial condition remain elusive. IBD is a term for a broad spectrum of diseases, but Crohn's disease and Ulcerative colitis are together termed as Inflammatory Bowel Disease (IBD). The pathogenesis of IBD may involve four major areas: it appears to be immunologically mediated, microbial dysbiosis is usually present, environmental factors trigger symptoms and genetic predispositions may play an important role. Altered immune response is common in both Crohn’s disease and UC. As a hyper-immune response plays an important part in IBD, immunomodulators and immune-suppressives have been used as a standard treatment for IBD. Corticosteroids and 5-aminosalicylates have been the traditional treatments for IBD. This study can be helpful for reducing the need of steroids and surgical processes in the patients of ulcerative colitis. There is no direct discussion about IBD in unani literature but instead discussed under the head of Zusantariya / Sahej / Ishaal as lesions of Intestine which manifests based on whether upper intestine(Ilium) or lower intestine (colon) is affected. The unani definition of this intestinal disorder is “Passage of stool admixed with blood or mucoid or stool or all the three together”. The cardinal symptom of IBD is “blood-mucoid diarrhea” which is observed in Zusantariya. It is also denoted as “Sahej” which means erosion of intestinal mucosa which is frequently seen with IBD in the form of ulcers. In unani literature Safra & Balgham-e-shore is considered as few of the causes among others which when fall (affect) on intestine, damages the intestinal mucosa and scrape off the mucous coating. This scraped off mucous pass along stool admixed with blood - hallmark of IBD. Unani treatment for Crohn's disease and Ulcerative colitis may offer help to protect and restore the digestive tract against damage and prevent the development of further complications of these diseases.
Keywords: Crohn’s disease, uveitis, disbiosys, immunomodulators, BMI.
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