European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF VARIATION OF HEMATOLOGICAL PARAMETERS AT RATTUS NORGEVICUS

Obou Constantin Okou*, Gomé Michel Bleu, Allali Eugène Koffi, Assandé Francis Ehounou and
Alain Dit Philippe Bidié

ABSTRACT

Background: Hematological evaluation in animals is of capital interest in defining the diagnosis of many diseases. The variation of hematological parameters, i.e. the haemogram (red blood cells, white blood cells, haemoglobin, haematocrit, MCV, MCH, MCHC, platelets, neutrophils, lymphocytes and MXD) is an indicator of the state of health. Materials and Methods: Thus in this study, to be able to determine the normal values of the rats, a set of batches of male and female Wistar rats was formed and acclimatized for 2 months. Each batch set consisted of thirty-nine (39) rats. Each rat was weighed and then by caudal venipuncture to collect their blood in an EDTA tube. The EDTA tube was used to do the blood count. Results: The results of this study showed that some animals already had certain pathologies before the use of any beneficial or harmful substance on them. However, most of the animals used had normal hematological parameters, indicating good health status. Conclusion: These values of determined standard haematological parameters may form a basis for future tests.

Keywords: Rats, hemogram, normal values.