BIOADHESIVE BUCCAL FILMS FOR THE DELIVERY OF BENZOCAINE
Malak Al-Hazel, Elarabi Khalil and *Mahmud Treki
ABSTRACT
Bioadhesive films, containing Benzocaine, were formulated to be adhered to the buccal mucosa for a period of time long enough to relieve the usual mouth lesions and pain. To achieve such an objective, formulations A, B, C, and D were developed to make films of different proportions of Psylium Husk (PSH) in combination with other hydrocolloids using film casting technique. The strength of bioadhesion of selected films to the mucous membrane of the stomach tissues, obtained from a sacrificed albino rabbit, was examined. Film D4 which is composed of carboxy-methylcellulose (CMC) and PSH showed the highest force required for detachment from the stomach tissue (83.33 ± 2.31 mN/m), while films composed of PSH and hydroxyethylcellulose (HEC) came second in terms of the tendency of adhering to the rabbit stomach ( film A8) . In Vitro drug release from various films in either distilled water or simulated saliva solution was conducted at 37.0 °C. The highest percentage of drug released was noticed when the percentage of PSH was about 41% w/w in the film matrix (film A8) with about 98% drug release after 4 hrs. Benzocaine release from films of different thicknesses, revealed that the release rate constant K was found to be independent of film thickness in full agreement with Higuchi’s diffusion controlled mechanism.[1]
Keywords: Bioadhesion, buccal films, Psylium Husk (PSH), carboxymethylcellulose (CMC), hydroxyethyl cellulose (HEC), Stearic acid (SA), Bnzocaine.
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