European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT, OPTIMIZATION AND INVITRO EVALUATION OF ROSIGLITAZONE MOUTH DISSOLVING TABLETS

Mumtaz Begum and Pamu Sandhya*

ABSTRACT

In the present work an attempt has been made to develop mouth dissolving tablets of Rosiglitazone. The objective of the current study is to develop and optimize mouth dissolving tablets of Rosiglitazone which is an effective drug in the treatment of type II diabetes mellitus. Rosiglitazone containing tablets were prepared by direct compression method using different superdisintegrants such as Crospovidone, croscarmellose sodium, sodium starch glycolate and other ingredients like mannitol, aspartame and magnesium stearate. The tablets were evaluated for physical properties including hardness, weight variation, thickness, friability, drug content, wetting time, water absorption ratio, in-vitro disintegration time, in-vitro dissolution study and also drug release kinetic study. The hardness, weight variation, thickness, friability and drug content of tablets were found to be acceptable according to pharmacopoeial limits. Optimized tablet formulation F9 was found, which provided short wetting time of 52 sec, in-vitro disintegration time of 26 seconds. From the above results, it indicated that the amount of super disintegrant i.e. crospovidone was significantly affected the wetting time, water absorption ratio and in-vitro disintegration time. The best in-vitro drug release was found to be in formulation F9 i.e., 99% at the end of 29 sec .All the formulations followed the zero order release kinetics with diffusion mechanism.

Keywords: Rosiglitazone, super disintegrants, Wetting time, Water absorption ratio, in-vitro dissolution study, zero order release kinetics.