Abstract
EXPERIMENTAL STUDY OF THE ALKANIZING EFFECT OF ETHANOL AND AQUEOUS EXTRACTS OF CURCUMA LONGA L. ON URINARY ACIDITY IN WISTAR RATS

SANGARE M. Machioud*, GUINNIN F. Félix, ISSOTINA Z. Abdoulaye, AKPO Jean-Michel, SEMADO F. Médard, GBANKOTO O. Adam, SEZAN Alphonse, ATEGBO N. Jean-Marc, DRAMANE K. Laye

ABSTRACT

The development of traditional therapies as pharmacological drugs to treat acidosis is becoming increasingly worrying. A number of medicinal plants have shown promising activity. The aim of this study was to evaluate the alkaline effect of ethanolic and aqueous extracts of Curcuma longa L. in wistar rats. For this purpose, we carried out an ethanolic extraction on the one hand with Curcuma longa L. powder and 90°C ethanol and an aqueous extraction on the other hand with Curcuma longa powder and distilled water. We then proceeded to force-feed 16 wistar rats in 6 batches. The administration of the extracts was carried out every morning over 7 days at two doses (0.4 and 0.8mg/kg body weight) after direct pH measurement with strips. At the end of this extraction, we obtained a yield of 8% in aqueous extraction and 6.5% in ethanolic extraction. The results showed that the administration of 0.4mg/kg and 0.8mg/kg body weight of aqueous and ethanolic extracts of Curcuma longa L. powder in wistar rats had a significant alkaline effect on the urinary pH of the latter. Although all extracts reached their maximum action at D7, the ethanolic extract at 0.8mg/kg body weight was more effective. The ethanolic extract was more effective than the aqueous extract. The maximum action of all the extracts was pH 9. All in all, Curcuma longa L. has a significant alkaline effect. This study could be repeated on a large sample of wistar rats in order to confirm or refute the results of the present study. These studies could address the toxicity of the latter mainly on the liver and kidneys of wistar rats.

Keywords: Curcuma longa L., alkalizing effect, wistar rats, acidosis, Benin.


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