European Journal of Biomedical and Pharmaceutical Sciences

HEPATIC CELL TARGETED DRUG DELIVERY SYSTEM: A REVIEW

Karunakar Prasad Dwivedi*, Amresh Gupta, Arpita Singh and Swarnima Pandey

ABSTRACT

Few of the hepatic diseases that cannot be effectively cured by some reasons because there are various receptors existed in the liver. In this time, several passive targeted drug delivery systems have been used in the drug/gene delivery in the treatment of hepatic diseases. More importantly, different measures would be taken in accord to the specified cell that was lesioned or dysfunctioned via interaction between homing ligands and target receptors so as to improve accumulation of drugs in the target cell and to reduce nonspecific toxicity towards other cells or organs. Many serious liver diseases affecting millions of people world-wide cannot be treated despite many efforts which warrant a search for new therapeutic strategies. Potent drugs may not be effective enough in-vivo or exhibit adverse effects and enhanced delivery into the target cells may improve this significantly. We aim to summarize the available options for drug delivery to the different intrahepatic cell-types.

Keywords: Liver targeted drug delivery, Hepatic disease, Nonspecific toxicity.