ANTIASTHMATIC STUDIES ON LEAF EXTRACT OF TRAGIA PLUKENETII R. SMITH AND T. INVOLUCRATA L.
Kalaivanan M., L. Louis Jesudoss, A. Saravana Ganthi* and M. Padma Sorna Subramanian
ABSTRACT
Asthma is a common, chronic inflammatory disease of the airways that affects people of all ages and imposes a substantial burden on patients, their families, and the community. Among India’s 1.31 billion people, about 6% of children and 2% of adults have asthma. Many medicinal plants are used to treat asthma in Ayurveda and Siddha system of medicine. The present study was undertaken to investigate the effect of the leaf extracts of Tragia plukenetii and Tragia involucrata for its antiasthmatic activity. The anti-asthmatic activity was carried out on isolated guinea pig ileum preparation (in-vitro) and histamine induced bronchospasm in guinea pigs. The present observations showed that the ethanolic extract of leaves of T. plukenetii and T. involucrata significantly inhibited (p < 0.05) the contractile effect of histamine. Ethanolic extracts of both medicinal plants were found to inhibit (p<0.05) bronchospasm induced by histamine in guinea pigs by varying degree. Although these results provide a support for the traditional uses of T. plukenetii and T. involucrata as anti-asthmatic action, further studies are necessary to better evaluate its safety and modes of action.
Keywords: Anti-asthmatic, Bronchospasm, Guinea Pig, Histamine Tragia plukenetii, Tragia involucrate.
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