Abstract
DEVELOPMENT AND EVALUATION OF MEDICATED CHEWING GUM CONTAINING ONDANSETRON HYDROCHLORIDE

Suraj Yadav*, Sandeep Atram, S. D. Pande and Nishan N. Bobade

ABSTRACT

Chewing Gums are mobile Drug Delivery Systems, with a potential for administering drugs either for local or systemic absorption via buccal route. It can be administered discreetly without water. Medicated Chewing Gums contains gum base along with Antiemetic agent which is intended to chew not to be swallowed. Also this formulation contains Polyisobutylene, Soya lecithin, Calcium Carbonate and Flavoring agents. The Medicated Chewing Gums were prepared by the direct compression method. The prepared formulations were evaluated for various pre-compression and post compression parameters. The in-vitro drug release of Formulation MCG3 showed satisfactory drug release within 30 min. at various chewing conditions. From the results it is concluded that the Chewing Gum Containing Ondansetran HCl will be the potential dosage form for the treatment of chemotherapy induced nausea and vomiting.

Keywords: Medicated Chewing Gum, Ondansetron Hydrochloride, Buccal Route, Nausea And Vomiting.


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