European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS OF MONTELUKAST SODIUM

Rafath Nazneen and Pamu Sandhya*

ABSTRACT

In the present study an attempt has been made to develop and formulate controlled release gastroretentive floating tablets of montelukast Sodium by using HPMC K100M, xanthan gum, guar gum as drug release retardants. Montelukast sodium is a leukotriene receptor antagonist (LTRA) administered as oral tablets at high doses 2-3 times per day. Hence in the present investigation, it is aimed to develop effervescent floating tablets of montelukast inorder to reduce frequency of dosing, achieve maximum gastric residence time and to improve drug availability. The tablets were evaluated for physical properties including hardness, weight variation, thickness, friability, drug content. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were evaluated for post compression parameters such as hardness, thickness, friability, percent drug content, weight variation tests and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F11 formulation with HPMC K100M, ethyl cellulose and sodium bicarbonate as gas generating agent provides the 99.32 % of drug release up to 12hours. The drug release from the optimized formulation followed both zero order and Higuchi kinetics. The results of the present study cocludes that gastroretentive floating tablets for montelukast were successfully formulated by using different grades of hydrophilic polymers such as HPMC K100, xanthan and guargum.

Keywords: Montelukast, HPMC K100M, xanthan gum, guar gum, gastroretentive floating tablets.