Abstract
FORMULATION AND EVALUATION OF FELODIPINE LOADED CHITOSAN NANOPARTICLES

Sunil Kumar Batra* and Dr. Satish Sardana

ABSTRACT

The main objective of the present study was to develop and optimize chitosan nanoparticles of Felodipine by Design of Experiments (DOE). Modified ionic gelation technique was employed for preparation of chitosan nanoparticles due to poor aqueous solubility of Felodipine. The effect of critical formulation variables like, chitosan concentration, TPP concentration, surfactant concentration and process variable like rate of homogenization were studied for the particle size distribution; drug entrapment efficiency and process yield. The dependent variables of the formulations were optimized using 32 full factorial designs and defined in mathematical equations. The desired values of response variables were found by response surface plots and contour plots generated using the design-expert® 10 software. The design was validated by check point analysis. Particle size, drug entrapment efficiency and process yield for the optimized batch were found to be 77.08 nm, 40.63 % and 59.87 % respectively. Thus, using systematic factorial design approach, desired goals can be achieved in shortest possible time with least number of experiments.

Keywords: Chitosan, Design of experiments, Felodipine, Nanoparticles.


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