European Journal of Biomedical and Pharmaceutical Sciences

CHRONIC MYELOID LEUKEMIA, ULCERATIVE COLITIS AND NEPHROTIC SYNDROME: WHAT IS THE RELATIONSHIP?

Dr. Hemant Mehta*, Dr. Abhay Bhave, Dr. Wasiyeeullah Shaikh, Dr. Bhagyashree Gorakh, Dr. Pallavi Tanpure and Dr. Naval Kazi

ABSTRACT

Membranous nephropathy could be primary or secondary to variety of conditions. It is essential to differentiate the two, which is difficult at times, but necessary to plan the appropriate treatment. We are reporting a case of chronic myeloid leukemia (in loss of remission status) and ulcerative colitis (clinically in remission), who developed membranous nephropathy and presented with acute kidney injury. He was advised to be treated with rituximab elsewhere, for presumed primary membranous nephropathy. On our analysis, it appeared to be a case of membranous nephropathy secondary to chronic myeloid leukemia, and the treatment of the underlying disease resulted in remission of nephrotic syndrome.

Keywords: chronic myeloid leukemia, nephrotic syndrome, membranous nephropathy, acute kidney injury, imatinib mesylate, rituximab.