European Journal of Biomedical and Pharmaceutical Sciences

ANTIMICROBIAL RESISTANT PROFILE OF BACTERIAL ISOLATES IN THE INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL IN BANGLADESH

*Dr. Sanjida Khondakar Setu and Dr. Abu Naser Ibne Sattar

ABSTRACT

Background: Infections with resistant strain are the leading causes of morbidity and mortality in intensive care unit (ICU).Patients admitted into the ICU usually have impaired immunity and are therefore at high risk of infections. Infections by multidrug resistant organisms constitute a major problem, limiting the choice of antimicrobial therapy. Objectives: This study was aimed at determining the antimicrobial resistance pattern of pathogens causing ICU infections in Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The aetiological agents, prevalence and types of ICU infections were also determined. Materials and Method: An observational study was carried out from January 2019 to December 2019. Blood, Foleys catheter tip, central venous line and tracheal aspirateswere collected and sent to the Microbiology laboratory. All pathogens were isolated and identified by standard microbiological methods. Disk diffusion antibiotic susceptibility testing was performed and interpreted according to Clinical and Laboratory Standards Institute guidelines Results: Out of the 673 tested sample 31.64% showed growth of pathogens among which the most prevalent samples were tracheal aspirates (70.76%) followed by blood (21.26%). The predominant isolate was Acinetobacterspp (39.43%) followed by Pseudomonas spp(25.82%), E coli (13.61%), Klebsiellaspp (13.14%) and Staphylococcus aureus (7.98%)respectively. Most isolates were resistant to Amoxicillin, Cephalosporins and Quinolones group of Antibiotics. E coli showed 100% sensitive to Colistin Conclusion: High prevalence of multidrug resistant bacteria causing ICU infections. Application of more stringent infection control procedures and antimicrobial stewardship are recommended to combat this problem.

Keywords: Intensive care unit, Antibiotic resistance, Infection control.