European Journal of Biomedical and Pharmaceutical Sciences

A BRIEF REVIEW ON MICROSPHARES

Kamlesh Maurya*, Amresh Gupta Arpita Singh, Swarnima Pandey, Nitish K. and Md. Aqil Siddhiqui

ABSTRACT

Microspheres are the many molecular drug delivery systems which are consist from natural and synthetic material. Microsphere make drug bioavailable, stable and target the drug to specific site at predetermined rate and it is particularly used in novel drug delivery system. Microspheres are features free flowing powders having particle size ranging from 1-1000 μm consisting of proteins or synthetic polymers. The techniques for the preparation of microspheres provides various options to control as drug administration aspects and increased the therapeutic efficacy of a given the drug. The microspheres delivery system is very useful and it give many advantages compared to others dosage forms, which include efficacy of drugs, reduced the toxicity of drugs, improved patient compliance and convenience. Such as system often use macromolecules as carriers for the drugs. The many types of microspheres are available such as Bioadhesive, Magnetic, Floating, Radioactive, Polymeric microspheres, Biodegradable polymeric microspheres, Synthetic polymeric microspheres etc. The Solvent Evaporation, Spray Drying, Single and double emulsion technique, Phase separation coacervation technique, Spray drying and spray congealing, Solvent extraction, emulsion solvent diffusion etc. are the most important methods of preparation of microspheres. Microspheres have large area of applications because of controlled and sustained release.

Keywords: Microspheres, Types, Preparation, Application.