EXPLORING POTENTIAL EFFECT OF ROSMARINUS OFFICINALIS IN VINCRISTINE INDUCED NEUROPATHIC PAIN IN RATS
Shivani Salokhe*, Shubhangi Deshpande, Swati Kolhe, Sachin Tembhurne
ABSTRACT
The objective of the present investigation was to evaluate the effect of Rosmarinus officinalis in vincristine induced neuropathic pain in rats. In the present investigational animal model, Vincristine sulphate (50 μg/kg i.p.) for 10 consecutive days was administered to induce neuropathy in rats with Rosmarinus officinalis. Rosmarinus officinalis has been used to determine the degree of mechanical thermal sensation of the spinal cord in tail immersion, paw pressure and acetone drop tests respectively. The levels of various antioxidants were determined to assess oxidative stress. In vincristine induced neuropathy models, co‑administration of Rosmarinus officinalis 100 mg/kg for 14 days significantly diminished reduction of nociceptive threshold in tail heat immersion test and threshold in paw pressure along with the increased score in the acetone drop test. Rosmarinus officinalis significantly attenuated reactive changes in increased oxidative stress for 14 days (100 mg / kg). The observed neuroprotective effect can be attributed to the antioxidant property of Rosmarinus officinalis. Therefore, with support from the literature and data in hand it seems quite evident that Rosmarinus officinalis at 100 mg/kg exerted its beneficial effects in vincristine induced peripheral neuropathic pain.
Keywords: Antioxidants, Rosmarinus officinalis, Vincristine, Neuropathic pain.
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