European Journal of Biomedical and Pharmaceutical Sciences

RECEPTORS PROFILE AND ITS CORRELATION WITH AGE AND MENOPAUSAL STATUS IN CARCINOMA BREAST PATIENTS-AN EXPERIENCE FROM A TERTIARY CARE HOSPITAL OF WESTERN UP

Dr. Surabhi Gupta*, Dr. Pooja Kumari

ABSTRACT

Introduction: Breast cancer is now the most common cancer among Indian females. Since immunohistochemistry is not routinely done in most of the center. We sought to analyze the association of hormone receptor profile with age distribution and menopausal status. Material and method: We conducted a retrospective analysis of 110 treated breast cancer patients at our center from Jan 2018 to Dec 2019. Individual patient’s receptor status was analyzed and correlated with age distribution and menopausal status of patients. Result: A total 110 breast cancer patients were evaluated. Total 49.09% patients were ER positive. HER neu- 2 overexpression was observed in 40% of patients while 25.45% patients were triple negative. Lowest receptor positivity was seen in age group of 41-50 years and maximum numbers of triple negative patents were also in age group of 41-50 years. Conclusion: Age but not menopausal status is a variable factor for receptor .The worst prognostic imunohistopathological characters are associated with younger age which is one decade earlier than western countries so these age groups require extensive screening protocol to follow. Immunohistochemistry should be mandatory investigation in carcinoma breast patient.

Keywords: Breast cancer, Receptor profile, Age group and Menopausal status.