Abstract
RELATIONSHIPS BETWEEN SERUM HORMONE LEVELS AND SEMEN QUALITY AMONG INFERTILE SUDANESE MEN AT ANDROLOGY CLINIC, KHARTOUM STATE, SUDAN

Sharaf Eldeen R. I.*, Akasha A. S., Kafi S. K., Badawi S. B. and Musa H. A.

ABSTRACT

Background: Semen analysis and hormone evaluation are essential parameters in giving a definitive diagnosis in infertile males. Abnormal hormone production has been noted as a male causative factor and hormonal replacement could play a corrective role. This study aimed to determine the seminal fluid parameters (volume, viscosity, count, motility and morphology) and to assess the fertility hormone profile (Follicular stimulating hormone (FSH)), Testosterone and Prolactine (PRL)) among infertile Sudanese men in Khartoum state. Methods: A total of 518 infertile men were recruited to participate in this study. Semen specimen was collected from each participant either by masturbation or coitus interruptus in a sterile container. Five hundred and eighty venous bloods were collected under aseptic condition into heparinized container. After centrifugation (5,000 rpm) for 5min., the plasma was separated from packed cells and 50μl was used for hormonal analysis. The (FSH), Testosterone and PRL levels were investigated for each sample using automated immunoassay analyzer (Tosoh Bioscience, Japan). Results: The mean serum level of FSH (33.79 7.05 ng/ml) and Prolactin (480.76 77.63 ng/ml) were significantly higher among individual with inadequate sperm count (P .value: 0.003 and 0.002) respectively, while the serum level of Testosterone (8.40 7.56 ng/ml) was significantly lower in the group of men with inadequate sperm count (P.value:0.007). The mean level of FSH (39.87 5.19 ng/ml) and Prolactin (463.95 52.32 ng/ml) were significantly higher in the group of men with primary infertility (P. value: 0.05 and 0.01) respectively, while the mean level of testosterone (7.34 8.13 ng/ml) was significantly lower (P. value: 0.00). The mean fertility hormone levels (FSH, Prolactin and Testosterone) were within the normal reference value among the group of secondary fertility and fertility checkup males. Conclusion: Hormonal fertility profile assessment must be performed as part of the routine investigation of male infertility as their levels were found to highly affect sperm count and other seminal parameters.

Keywords: Hormonal profile, Semen, infertility, Khartoum, Sudan.


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