European Journal of Biomedical and Pharmaceutical Sciences

DIFFERENCE IN THE METABOLISM OF COLD- AND WARM-BLOODED ANIMALS AND ITS MITOCHONDRIAL MECHANISMS

Akmaljon Usmonjonovich Najimov, Rashid Nasipovich Akhmerov, Gafurjan Rakhimjanovich Abdullayev, Bahadir Allaberganovich Niyazmetov*

ABSTRACT

It was studied the intensity of the oxygen consumption by whole organisms in cold and warm-blooded animals. It was revealed that cold-blooded species of animals (steppe turtle, water snakes etc.) have a very low metabolism, the level of which is about 10 times lower than in warm-blooded rats. These data are consistent with literature data obtained on other animals. The authors asked themselves about the mechanisms of such a high difference between animals. In particular, it was found that the tissues mitochondria of warm-blooded animals, in contrast to cold-blooded ones, carry out coupled respiration with the ATP synthesis, as well as with uncoupled respiration. It was shown that the functioning of uncoupled respiration is a thermogenic mechanism that determines the warm-blooded state of organisms.

Keywords: Metabolism, cold- and warm-blooded animals, heat production, uncoupled respiration, oxygen consumption, ATP.