European Journal of Biomedical and Pharmaceutical Sciences

GLYCOSYLATED HEMOGLOBIN PROGNOSTICATES DYSLIPIDEMIA-A RETROSPECTIVE STUDY

Syed Ali Khizer* and Yashasvine Dandothikar

ABSTRACT

Our study aimed to find utility of HbA1c as indicator of dyslipidemia in patients with type 2 diabetes mellitus. This study is an attempt to determine the correlation between hemoglobin A1c (HbA1c) and serum lipid profile and to evaluate the importance of HbA1c as an indicator of dyslipidemia in South Indian Patient with T2DM. Total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and HbA1c levels were evaluated. Test of significance was calculated by unpaired Student's 't' test. Correlation studies (Pearson's correlation) were performed between HbA1c and serum lipid profile. Significance was set at p<0.01. Significantly higher mean serum levels of TC, TG and LDL-C and significantly lower mean serum levels of HDL-C were noted in patients with diabetes. Significant correlations were observed between HbA1c value and serum levels of TC, TG and HDL-C (p<0.01) but no significant correlation of HbA1c value with LDL-C in-diabetes patient. Apart from a reliable glycemic index, HbA1c can also be used as a predictor of dyslipidemia and thus early diagnosis of dyslipidemia can be used as a preventive measure for the development of CVD in patients with T2DM.

Keywords: HbA1c, dyslipidemia, Correlation, Retrospective Study.