European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF ANTIDIARRHEAL ACTIVITY OF ETHANOLIC ROOT EXTRACT OF GLYCYRRHIZA GLABRA LINN. IN RATS

Deeksha Sharma, Rahul Saxena, Priyanka Namdeo* and Priti Singh

ABSTRACT

Diarrheal diseases are a major public health problem in developing countries. The present study was undertaken to evaluate the effects of ethanolic extract of roots of Glycyrrhiza glabra on castor oil-induced diarrhea and magnesium sulphate-induced diarrhea method were examined. Each model consisted four groups, control, standard (loperamide), Glycyrrhiza glabra root extract 150 mg/kg and 300 mg/kg were used. It was noticed that the fecal weight was reduced in the doses 150 and 300 mg/kg significantly in comparison to control. The extract dose (300 mg/kg) was significantly choose for reducing the diarrheal condition in experimental rats. The extract was found to inhibit peristaltic movements of secretions in castor oil induced and magnesium sulphate induced model confirming its antidiarrheal activity, which might be due to its high flavonoid content. The results provide evidence that the ethanolic extract of Glycyrrhiza glabra root possesses antidiarrheal activity and could be accounted for pharmacological effects and Herbal medicine.

Keywords: Glycyrrhiza glabra, Diarrhea, castor oil, Antidiarrheal.