European Journal of Biomedical and Pharmaceutical Sciences

ESTIMATION OF CORRELATION BETWEEN QUALITY OF LIFE AND DURATION OF DISEASE IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS

Tashpulatova M.M.*, Nabiyeva D.A., Ganiyeva N.A., Aripova N.A., Rakhmatullaeva G.K. and Sharapov Z.N.

ABSTRACT

Being one of the rheumatologically diseases occurring with articular syndrome (AS), rheumatoid arthritis (RA) is characterized by damage to functionally important joints, which leads to disability of patients, especially among young and middle-aged people, which determines the social significance and urgency of the problem. The study of the quality of life in rheumatology is a highly informative method for assessing the condition of patients and allows you to get an idea of the impact of the disease on various spheres of human life. The aim of this study was to assess the quality of life (QOL) of patients with early RA depending on the duration of the disease based on the data of the SF-36 questionnaire in comparison with standardized indicators of population control. Material and methods The study included 68 patients aged 19 to 74 years with a reliable diagnosis of RA (meeting the EULAR / ACR criteria, 2010) with a disease duration of up to 1 year. General clinical, biochemical, and immunological blood tests were used to diagnose and determine the activity of RA disease. The impact of the disease on QOL was assessed using the SF-36 questionnaire. The QOL parameters of RA patients were assessed by the timing of the onset of the disease and compared with the standardized indicators of the population control group. Depending on the duration of the disease, the patients were divided into 4 groups: I group (16 patients) onset of the disease was 3 months, II group (17 patients) - the duration of RA was up to 6 months, III group (16 patients) consisted of patients with RA up to 9 months and the IV group (19 patients) included patients with the disease duration up to 12 months. Results Our data show that RA is accompanied by a decrease in physical health indicators, at the same time, the total psychological component of their health did not differ from the population one. In the general group of RA patients examined by us, lower values of the quality of life were noted than in the population control according to scales reflecting such mental components of health as vitality and social functioning; however, when comparing these indicators in individual age groups, these differences were completely leveled. In conclusion, it should be emphasized that our results demonstrate a low QOL of patients with RA, reflecting, first of all, changes in physical health. These data determine the social significance of RA and the need for a more in-depth study of the problem; QOL should also be taken into account when assessing the effectiveness of the treatment given to these patients.

Keywords: Early rheumatoid arthritis, disease duration, quality of life.