European Journal of Biomedical and Pharmaceutical Sciences

DESIGN, PREPARATION AND IN VITRO CHARACTERIZATION OF DULOXETINE THE TRANSDERMAL PATCH

*B. Sridhar and Dr. G. Praveen Kumar

ABSTRACT

Transdermal drug delivery (TDD) is an acceptable mode of drug delivery for administering the drug into the body across the skin. Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. The formulation developed by using polymers such as Ethyl cellulose n45, HPMCk15m polymers are used in different trails in different quantity is used. The Dibutyl phthalate is used as plasticizer and DMSO (Dimethyl sulfoxide) used as permeation enhancer. The formulation s F1-F9 are formulated. After completion of formulation the evaluation parameters are performed. The evaluation parameters values for optimized formulation such as, The Thickness of the transdermal patch is found to be,0.28, The drug content study was found to be, 98.89 %, The moisture loss studies found to be, 7.68%, The moisture absorption studies found to be, 10.46%, The weight variation of patch was found to be, 199mg, The In-vitro drug release studies found to be, 99.34, The all performed evaluation parameters are found to be values within the limits of range.

Keywords: Duloxetine, Transdermal patch, Ethyl cellulose N45, Hpmck15m.