European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF THE MELOXICAM MOUTH DISSOLVING TABLETS

*B. Divya and Dr. G. Praveen Kumar

ABSTRACT

Formulation, development, in vitro characterization of the Meloxicam mouth dissolving tablets. For development of the tablets different excipients are used. The used various excipients such as theccs, Mg.sterate,Talc,,MCC, pvpk30used as the diluents The formulation is developed by the using direct compression method. The formulation is prepared by using different excipients. The excipients are ccs, in various compositions for drug to release prolong time. The pre compression parameters are done such as the bulk density, tap density, compressibility index, Hauners ratio, Angle of repose. The all parameters are come under within range goof flow. The post compression parameters are done such as the harness, thickness, weight variation, friability, disintegration. The evaluation parameters of the optimized formulation F9 values:The weight variation of orodispersable tablets, 199mg.The hardness of the orodispersable tablets, 3.7(Kg/cm2)Thickness of the orodispersable tablets, 2. .42mm. Disintegration of the orodispersable tablets, 3min. Drug content of the orodispersable tablets, 97.86%. Friability of the orodispersable tablets, 0.56%. In-vitro drug dissolution studies of the orodispersable tablets,96.23%. The all parameters come under acceptable criteria within range of limits. The In-vitro drug release studies are done by USP-II apparatus paddle method. The optimized formulation F9 gives the prolong release up to 30mins the drug release 96.23%

Keywords: Meloxicam, Mouth dissolving tablets, Mg.sterate, Talc,, MCC, pvpk30.