European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUTION OF TRANSDERMAL DRUG DELIVARY SYSTEMS CONTAINING NICOTINE

J. Chakri* and A. Kiran Kumar

ABSTRACT

Transdermal drug delivery systems (TDDS), also known as “patches,” are dosage forms designed to deliver a therapeutically effective amount of drug across a patient‟s skin. Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is both a sedative and a stimulant. was selected for the formulation of transdermal delivery system as it complies with physicochemical properties required to permeate through skin. The preformulation studies involving description, solubility, melting point, partition coefficient of the drug were found to be comparable with the standard.The patches were prepared by solvent casting technique. The patches were subjected to the following evaluation parameters such as physical appearance, weight variation, thickness, folding endurance, drug content, percentage moisture absorption, percentage moisture loss, water vapour transmission rate, tensile strength, diffusion studies and skin irritation studies. All the parameters were within the limits. Based on all these results viz. mechanical properties, compatibility, stability and diffusion studies, formulation A3 was selected as the best formulation. From in vitro and skin irritation test, it can be concluded that the developed formulation A3 have great potential for transdermal drug delivery.

Keywords: Nicotine, Transdermal drug delivery system, Sodium alginate, Xanthan gum.