Abstract
FORMULATION AND EVALUTION OF TRANSDERMAL DRUG DELIVARY SYSTEMS CONTAINING NICOTINE

J. Chakri* and A. Kiran Kumar

ABSTRACT

Transdermal drug delivery systems (TDDS), also known as “patches,” are dosage forms designed to deliver a therapeutically effective amount of drug across a patient‟s skin. Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is both a sedative and a stimulant. was selected for the formulation of transdermal delivery system as it complies with physicochemical properties required to permeate through skin. The preformulation studies involving description, solubility, melting point, partition coefficient of the drug were found to be comparable with the standard.The patches were prepared by solvent casting technique. The patches were subjected to the following evaluation parameters such as physical appearance, weight variation, thickness, folding endurance, drug content, percentage moisture absorption, percentage moisture loss, water vapour transmission rate, tensile strength, diffusion studies and skin irritation studies. All the parameters were within the limits. Based on all these results viz. mechanical properties, compatibility, stability and diffusion studies, formulation A3 was selected as the best formulation. From in vitro and skin irritation test, it can be concluded that the developed formulation A3 have great potential for transdermal drug delivery.

Keywords: Nicotine, Transdermal drug delivery system, Sodium alginate, Xanthan gum.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: APRIL ISSUE PUBLISHED

    APRIL 2021 Issue has been successfully launched on 1 April 2021.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT