Abstract
DESIGN AND DEVELOPMENT OF TRIMETAZIDINE HYDROCHLORIDE SUSTAINED RELEASE MICROSPHERES

*J. Prakash and Dr. G. Praveen Kumar

ABSTRACT

Trimetazidine hydrochloride-loaded Gelatin microspheres were prepared by the ionic cross-linking technique using TPP as cross-linking agent. The process induced the formation of microspheres with the incorporation efficiency of 47% to 77%. The effect of Gelatin concentration, cross-linking agents and conditions was evaluated with respect to entrapment efficiency, particle size, surface characteristics and in vitro release behaviors. Infrared spectroscopic study confirmed the absence of any drug-polymer interaction. Differential scanning colorimetric analysis revealed that the drug was molecularly dispersed in the Gelatin microspheres matrices showing rough surface, which was confirmed by scanning electron microscopy study. The mean particle size and entrapment efficiency were found to be varied by changing various formulation parameters. The in vitro release profile could be altered significantly by changing various formulation parameters to give a sustained release of drug from the microspheres. The kinetic modeling of the release data indicate that trimetazidine hydrochloride release from the Gelatin microspheres follow anomalous transport mechanism after an initial lag period when the drug release mechanism was found to be fickian diffusion controlled.

Keywords: Trimetazidine hydrochloride, sustained release, Microspeares.


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