European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUTION OF FLOATING TABLETS FOR INDOMETHACIN

S. Raju* and A. Kiran Kumar

ABSTRACT

Indometacin, or indomethacin, is a non-steroidal anti-inflammatory medicine (NSAID with anti-inflammatory, analgesic, as well as antipyretic residential or commercial properties. Gastric transit time is beneficial possession for dosage kinds, which stay in the stomach for a long period of time than traditional dose form. The preformulation parameters like organoleptic properties, angle of repose, bulk density, tapped density, Hausner’s ratio, carr’s index and compressibility index of pure drug was evaluvated and complied with the pharmacopoeial specifications. FTIR studies showed there was no interaction between drug and polymer. Gastro retentive floating matrix tablets of Indomethacin were successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M.,HPMC 100M. The formulated batches were evaluated for physicochemical parameters, floating properties and dissolution profiles. From the evaluation results, it was observed that the tablets contain the higher viscosity HPMC showed long floating lag time when compared to tablets prepared with lower viscosity HPMC. The physical properties like hardness, weight variation and friability of majority of the batches complied with the pharmacopoeial specifications. The drug content of all tablets was in the range of 95 – 100%.In vitro dissolution study of all the formulations was done in 0.1 N HCL. The release rate was faster with lower viscosity grades of HPMC, probably owing to less polymer entanglement and less gel strength and also to the larger effective molecular diffusion area at lower viscosity as compared with higher viscosity grades of HPMC. The tablets containing HPMC K4M (F2) showed satisfactory results with short floating lag time (68 sec) total buoyancy time more than 12 h, cumulative % drug release (99.33) and controlled drug release up to 12 h. So F2 was taken for kinetic studies. The kinetic studies were carried for formulation F2 showed high regression value of 0.9877 for zero order, 0.981 for Higuchi order (conforms non- Fickian sustained release) and N value greater than 5 (conformsdiffusion controlled) with complete release in 12 hrs made it to select as an optimized formulation compared with other formulations. The accelerated stability was carried for F2 formulation and shown no much change in physical parameters and cumulative % drug release. Hence formulation F2 conformed as stable.Hence it was concluded that formulation F2 choosen as optimum formulation.

Keywords: Indomethacin, floating tablets, HPMC K4M, HPMC K15M, HPMC 100M.