MICROWAVE SYNTHESIS OF NOVEL IMIDE DERIVATIVES AND THEIR ANTIOXIDANT POTENTIAL
Rajat Bisht* and Ajay Singh Bisht
ABSTRACT
Microwaves are in the form of electromagnetic energy which lie in electromagnetic spectrum corresponds to wavelength of 1cm to 1m and frequency of 30GHz to 300MHz. Imide is the form of amide in which the nitrogen atom is attached to two carbonyl group. Imide refers to any compound which contains the divalent radical. These compounds are derived from ammonia or primary amine, where two hydrogen atoms are replaced by a bivalent acid group or two monovalent acid groups, resulting in consisting of two carboxylic acid groups. Thus, the present communication utilized the technology beautifully for the synthesis, identification and characterization of some novel derivatives by the reaction of maleic anhydride with urea, glycine, aniline, sulphanilic acid to yield various maleimide derivatives using domestic microwave by getting percentage yield 92.86%, 90.64%, 86.70% and 55.53% of synthesized compound A1,A2,A3 and A4 respectively. The compound A1 (92.86%) showed higher percentage practical yield. All synthesized compound(s) were subjected to melting point determination, TLC analysis, column chromatography (for purification), 1H-NMR and Mass Spectrometry. All synthesized derivatives were subjected for DDPH scavenging activity, in which compound A3 was found to have high anti-oxidant potential (91.85%) when ascorbic acid was taken as standard. All the chemicals used were of highly pure and purchased from Central Drug House (New Delhi).
Keywords: Microwaves, Imide, Maleimide, Green chemistry, DDPH, Antioxidant.
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