European Journal of Biomedical and Pharmaceutical Sciences

“SYNTHESIS AND ANTIBACTERIAL ASSAY OF NANOPARTICLES OF IMMIDAZOLE DERIVATIVES OF ARYL SUBSTITUTED 1,3-THIAZOLE”

*Chhaya D. Badnakhe

ABSTRACT

The synthesis, spectral analysis and biological activities of 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (D”) have been carried out. In this case 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-amine-1,3-thiazole (D), 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-[(2-hydroxy-3,5-dichlorophenyl) ethanonylamino]-1,3-thiazole (D’) & 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (D’’) have been screened. The compounds (D), and was synthesized from 1-(2’- hydroxy-3’ ,5’-dichlor ophenyl)-2-bromo-3-(4”-nitrophenyl)-1,3 propanedione (a4) by the action of thiourea, while (D’’) was synthesized from (D) by reaction with α-bromo,2-hydroxy-3,5 dichloroacetophenone to get 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(4”-nitrobenzoyl)-2-[(2-hydroxy-3,5-dichlorophenyl) ethanonylamino]-1,3-thiazole (D’). Further (D’) on treatment with KSCN was dissolved in acetic acid gave (D’’). The nanoparticles of the compounds D, D’and D’’ have been prepared by using ultrasonic technique. The newly synthesized titled compound and it’s nanoparticles were screened for their antibacterial activities against some Gram positive Staphylococcus aureus and Streptococcus sp. and Gram negative Pseudomonas sp. and Solmonella typhi pathogens. All the newly synthesized compounds were found to be active against test pathogens.

Keywords: Chalcone, thiazine, thiourea, ?-bromo,2-hydroxy-3,5 dichloroacetophenone, KSCN was dissolved in acetic, antibacterial assay.