European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF CLINICAL FEATURES AND RISK FACTORS IN THE DIAGNOSIS OF PERFORATED DUODENAL ULCER

Dr. Weam Rashad Ismail*

ABSTRACT

This study aimed to determine the prevalence of perforated peptic ulcer (PPU) in patients admitted to Department of Al-Shahid Al-Sadr Hospital-Baghdad/Iraq during the period from November 2016 to November 2019, and describe the values of making the diagnosis on clinical bases with hope of achieving absolute cure. In this retrospective study, we examined the data derived from cases of 37 patients who were admitted and diagnosed as PPU. The patients had at least one or more risk factors leading to PPU (smoking, stimulants, non-steroidal anti-inflammatory drugs NSAIDS…). Those patients’ symptoms almost initiated about 24 hours prior to admission. Their age ranged between 19-79 years. Results showed that 27(72.9%) cases were diagnosed as perforated duodenal ulcer, and 10(27.1%) cases were diagnosed as perforated gastric ulcer (P.G.U), and 13(35.1%) cases were to be stimulant-induced perforated ulcer and as duodenal or gastric in 9 and 4 cases, respectively. Significant relation was found between drug-induced perforated ulcer D.I.U, smoking, other stimulants (coffee and tea) and hypertension. Furthermore, a significant relation was found between taking NSAID and each of PGU, P.D.U and (D.I.P.U). It can be concluded that the mean age of participants was 49 years old, and the males were more common 86.5% with a male to female ratio 6:1. The most common PPU was duodenal, and patients taking NSAIDs have a higher risk for developing gastric ulcer and D.I.U.

Keywords: PDU, NSAIDS, P.G.U, D.I.P.U