Abstract
SMART AND NOVELISTIC BIOFLEXIFILM FORMER LOADED WITH LAMOTRIGINE FROM THE SEEDS OF PHASEOLUS VULGARIS

Abhijeet Ojha*, Bhavna, Navin Chandra Pant and Navneet Tiwari

ABSTRACT

Objective: The aim of our research work was to isolate a biomaterial from Phaseolus vulgaris and evaluate its filmability. Phaseolus vulgaris was subjected for isolating the biomaterial in a simplified and economic process. The biomaterial was investigated for various physico-chemical tests as well as spectral analyses like IR, 1H NMR, DSC, XRD, SEM and elemental analysis. The mucoadhesivity of biomaterial was screened by rotating cylinder method. Methods: Lamotrigine loaded bioflexifilm were prepared using biopolymer, flexicizer and other co- processing agents for delivery of lamotrigine through oro-translabial mucosa. Result: The prepared films were evaluated for physical appearance, weight uniformity, thickness, folding endurance, surface pH, tensile strength, percent moisture uptake, vapour transmission rate, content uniformity and in-vitro drug diffusion using novel static M.S. diffusion apparatus. The results were compared with the standard HPMC film. The experimental results revealed that the biomaterial shows appreciable mucoadhesivity. The bioflexifilm LP6 possessed excellent folding endurance and 90.54 % drug diffusion through the biological membrane for a period of 36 hours. Conclusion: Finally conclusion was drawn that biopolymer exhibits inbuilt filmability, so it can be used as a bioflexifilm former for designing drug loaded bioflexifilms for translabial mucosal delivery.

Keywords: Labial drug delivery, Bioflexifilms, Labial mucosa, Phaseolus vulgaris.


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