Abstract
DEVELOPMENT & VALIDATION OF RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF CEFUROXIME INJECTION DOSAGE FORM

B. Sucharitha* and Prof. V. Anuradha

ABSTRACT

A new, simple, rapid, selective, precise and accurate isocratic reverse phase high performance liquid Chromatography assay method has been developed for estimation of Cefuroxime in injection formulations. The separation was achieved by using column Zodiac C8 (150 x 4.6mm, 5μm) mobile phase consisted of pH 3.4 acetate buffer and acetonitrile in the ratio of (10:1 v/v). The flow rate was 2.0mL.min-1. Cefuroxime was detected using UV detector at the wavelength of 254nm. The retention time of Cefuroxime was noted to be 3.08 min respectively. The method was validated as per ICH guidelines. The proposed method was found to be accurate, reproducible, and consistent.

Keywords: Liquid chromatography, Cefuroxime and Validation.


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