European Journal of Biomedical and Pharmaceutical Sciences

ROLE OF COMBINATION THERAPY (VALSARTAN PLUS HYDROCHLOROTHIAZIDE) IN HYPERTENSION: A REVIEW

Shubhangi Bhilla* and Gaurav Agarwal

ABSTRACT

Hypertension is one of the most prevailing disease in adults. The estimated prevalence of hypertension in the United States is 66% in men and women aged 60 years and older, which is the highest among all age groups. This figure is higher in certain regions of the world. Hypertension, in general involve multiple factors, hence treatment of hypertension with combination therapy has several advantage over monotherapy. In combination therapy, two or three drugs act through different mechanism and simultaneously lower dose of the individual drug is required hence reduce side effects and increase patient compliance. Combination therapy generally involve Angiotensin Receptor Blockers (ARBs) and Thiazide diuretics. Choice of combination depends on the presence of comorbidities like diabetes mellitus, chronic renal failure and thyroid disorders.

Keywords: Valsartan/Hydrochlorothiazide, combination therapy, hypertension.