European Journal of Biomedical and Pharmaceutical Sciences

MULTIPARTICULATE DRUG DELIVERY SYSTEM - A RECET NOVEL TRENS IN PELLET FORMULATION

Nisha C. Patel* and Dr. Hitesh A. Patel

ABSTRACT

The present time is considered as an era of advancements in drug delivery systems. Different novel approaches are under investigation that range from uniparticulate to multi particulate system, macro to micro and nano particulate systems. Pelletization is one of the novel drug delivery technique that provides an effective way to deliver the drug in modified pattern. The pelletization technologies are gaining much more attention as they represent as efficient pathway for manufacturing of oral drug delivery system. It is advantageous in providing site specific delivery of the drug. Drugs with unpleasant taste, poor bioavailability and short biological half-life can be delivered efficiently through pellets. Different techniques are used to fabricate the pellets such as extrusion and spheronization, hot melt extrusion, powder layering, suspension or solution layering, freeze pelletization and pelletization by direct compression method. Among various techniques, Extrusion/spheronization is the most widely utilized technique. The purpose of the current review is to discuss pellets, different techniques of pelletization and characterizations of pellets with its application to ensure its quality, safety and efficacy to give out the required therapeutic activity after administration.

Keywords: Pellets, Pelletization, Extrusion, Spheronization, Multiparticulate.