European Journal of Biomedical and Pharmaceutical Sciences

ANALYTICAL TECHNIQUES USED FOR THE DETERMINATION OF VILDAGLIPTIN AND ITS COMBINATIONS: AN OVERVIEW

M. Kavitha, R. Vijayageetha*, Bharani Pandilla, R. Saravanan and R. Santhosh Kumar

ABSTRACT

Vildagliptin is an oral antidiabetic drug it comes under the class of dipeptidyl peptidase-4 (DPP-IV) inhibitor. An analytical technique is a method used to identify and determine the concentration of a chemical compound or element. This article reviews reported analytical methods such as spectroscopy, electrophoresis, liquid chromatography, gas chromatography and some hyphenated techniques up-to-date for the determination of vildagliptin and its combinations in bulk drugs, pharmaceutical formulations and in biological matrices such as blood, plasma, serum, oral fluids, sweat, hair, urine, etc. Based on the survey in the analytical and pharmaceutical journals we summarized the most popular analytical technique used for the determination of vildagliptin and we concluded that the high-performance liquid chromatography was the most familiar and easy method used for the determination of vildagliptin. This review may direct the research scholars by providing information regarding the analysis of vildagliptin.

Keywords: Vildagliptin, anti diabetic drug, pharmaceutical formulations biological matrices, spectroscopy, chromatography.