European Journal of Biomedical and Pharmaceutical Sciences

PLATELET-RICH PLASMA – THERAPEUTIC CONSIDERATIONS IN REHABILITATION OF MUSCULOSKELETAL CONDITIONS

Daniela Poenaru*, MD, PhD, Lecturer and Delia Cinteza, MD, PhD

ABSTRACT

Since the first use of platelets for hemoragic conditions, in 1910, platelets received a continuous attention, giving their roles in hemoastazis, coagulation, and wound repair. There are four different catheories of blood preparation, L-PRP being by far the most available, easy to use and, consequently, studied. The regenerative action of platelets concentrate is based on the growth factors from the intracellular granules, associated with soma plasmatic bioactive proteins. There are also other presumed effects of PRP, analgesic and anti-inflammatory, that necessitate further documentation. Studies revealed a clear regenerative action when injected intraarticular into the osteoarthritic knee. Other conditions that respond to PRP local administration are some tendinopathies, like tennis elbow and ”harvesting” patellar tendinopathy. Surgery for ligament reconstruction or nerve suture, in the presence of PRP, offered better outcomes. Discogenic low-back pain was treated with intradiscal PRP and showed promise as for reducing recurrence and improving function.

Keywords: Platelet rich plasma, Tendinopathies, Surgery reconstruction.