European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF KETOPROFEN SOLID DISPERSION INCORPORATED TOPICAL GELS

Arun Raj. R*, Elwin Jose, Jyoti Harindran, 4Sreerekha. S

ABSTRACT

Solid dispersion technique is a promising method to improve the solubility of poorly water soluble drugs. Solid dispersions prepared with various carriers by solvent evaporation, fusion and kneading technique were effective in improving the solubility and dissolution of Ketoprofen. Ketoprofen is a potent NSAID which has analgesic and anti-inflammatory properties. Topical route for Ketoprofen was selected up to avoid GIT irritation and to maximize the drug concentration at the site of action. In the present study attempts were made to formulate and evaluate of Ketoprofen solid dispersion incorporated topical gels. Solid dispersions were prepared in various ratios using each carrier. Solubility study and dissolution study showed that as the concentration of the carrier increase, the solubility and dissolution rate of Ketoprofen increases. The particle size and surface morphology of solid dispersions were studied by SEM. IR studies showed that no chemical reaction was taken place between drug and carriers in solid dispersion. The powder X-ray diffraction study Ketoprofen - β-cyclodextrin dispersion showed that drug is present in amorphous form in solid dispersion, which could be the reason for solubility enhancement. The in-vitro and ex-vivo drug release were carried out using egg membrane and rat abdominal skin respectively in phosphate buffer pH 7.4. The ex- vivo release of drug from rat skin was plotted according to modes data treatment, to precisely know the mechanism involved in the drug release. The drug release mechanism from all the formulated gels was found to be predominantly diffusion controlled.

Keywords: Solid dispersion, Topical gels, Ketoprofen, In-vitro and ex-vivo release studies.