European Journal of Biomedical and Pharmaceutical Sciences

SUPER POROUS HYDROGEL TABLETS: NOVEL DRUG DELIVERY APPROACH

A. R. Chaudhari*, M. A. Raut, K. B. Gabhane and S. D. Pande

ABSTRACT

Super porous hydrogels (SPHs) are novel improvement in sustained release gastro retentive drug delivery system. Another gastro retentive drug delivery systems (GRDDS) includes mucoadhesive system, intragastric floating system (low density system), swellable system and high density system. SPHs system should swell instantly in stomach and should maintain their integrity in highly acidic stomach environment, while releasing the pharmaceutical active ingredients in stomach. First generation conventional SPH has poor mechanical strength that can be overcome by developing second generation composite SPH and third generation hybrid SPHs. Characterization can be performed by the measurement of porosity, apparent density, swelling studies and SEM studies.

Keywords: Super porous hydrogels (SPHs), gastro retentive drug delivery systems (GRDDS), Composite SPHs, hybrid SPHs, etc.