European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF INHALED CORTICOSTEROIDS ON GLUCOLIPOTOXICITY AND HIGH SENSITIVITY C-REACTIVE PROTEIN IN ASTHMA PATIENTS

Dr. R. Reeta*, Dr. Kulkarni Sweta, S. Krupashree, Dr. R. Pajanivel, Dr Ramesh. R

ABSTRACT

Background: Asthma is a chronic inflammatory disease which is treated using inhaled corticosteroids. Certain studies suggest that use of inhaled steroids may lead to a decrease in the levels of hsCRP. It has also been suggested that CRP might be used as a marker for systemic inflammation in case of asthma patients. On the other hand, it has also been seen that use of inhaled corticosteroids may increase the risk of developing diabetes mellitus and atherosclerosis. This study aims to evaluate and correlate the hsCRP, blood glucose, lipid profile and glycated albumin with the pulmonary function tests in patients undergoing short term inhaled corticosteroid therapy. Materials and Methods: The study was conducted on 30 patients attending the outpatient department in pulmonary medicine. Blood glucose, lipid profile, hsCRP and glycated albumin were measured in the patients, once before the start of treatment and once after six weeks.. The values were compared. A correlation analysis test was performed to see the relation of blood glucose, lipid profile and pulmonary function test with hsCRP and glycated albumin. Biochemical tests were done using IFCC approved methods. Results: This study documents increased levels of blood glucose, TAG and VLDL in asthma patients after treatment with ICS for one month. It also establishes a positive relation of ICS with pulmonary function. Conclusions: In our study, we have found significant changes in blood glucose, TAG and VLDL in patients who underwent inhaled corticosteroid therapy for a month. We were also able to record a significant improvement in the pulmonary function tests of these patients after treatment with ICS.

Keywords: Lipid profile, hsCRP, Inhaled corticosteroids, Glycated albumin, Glucolipotoxicity.