SHORT DISCUSSION ON SOLID DISPERSION: SOLUBILITY ENHANCEMENT TECHNIQUES
Pragati R. Katkide*, Sandeep C. Atram, Renu M. Awachar and Tanaz N. Nathani
ABSTRACT
The phenomenon of dissolution of solid phase in liquid phase to obtain a homogenous system is known as solubility. Many drugs, in particular, have poor solubility in water but we also know that water is the chief solvent of choice to be used for liquid pharmaceutical formulations. And thus, this poorly solubility ultimately affects the therapeutic plasma concentrations and also the bioavailability of the drugs. To ameliorate the dissolution of poorly water-soluble drugs as well ultimately ameliorating their bioavailability, the dispersion of one or more active pharmaceutical ingredients in a carrier that too at solid-state is used. This phenomenon is known as Solid dispersion. This solid dispersion is mainly applied to improve the solubility, dissolution rates as well as bioavailability of poorly soluble drugs. Various solid dispersions techniques have been described briefly in this review article. These techniques include the kneading method, adjustment of pH, co-precipitation, co-solvency, etc. In this article, further, we have studied the formulations, merits, and demerits as well as the characterization of the solid dispersions.
Keywords: Solubility; Solid dispersion; dissolution; solubility enhancement.
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