SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 1, 3, 4-THIADIAZOLE DERIVATIVES AS AN ANTI-INFLAMMATORY AGENTS
Pravin Sanjay Sake*, Dr. Manoj S. Charde and Dr. Rita D. Chakole
ABSTRACT
Inflammation is a defensive mechanism of the body to any toxic, chemical irritant, injury as well as infection; process may changing from a localized to a generalized. The symptoms of inflammation generally redness, heat, pain, edema and loss of function. Non-steroidal anti-inflammatory drugs commonly prescribed worldwide for management or reduce of pain and inflammation due capability to block COX enzyme which is production of prostaglandin mediators that‟s responsible for inflammation. Continuous use of non-steroidal anti-inflammatory drugs has been produce certain adverse effects in patients but two are commonly such as gastric intestinal ulceration and renal toxicity because inhibition of cytoprotective COX-1 enzyme. In order to developing NSAIDs drugs with minimum these side effects, this may be accompanied by drugs without contain acidic group (carboxylic as functional group). Thiadiazole derivatives and its analogous which show anti-inflammatory and analgesic activity and also reduce gastrointestinal ulceration as well as various other adverse reactions. That‟s why to synthesized compounds having the 1, 3, 4-thidiazole nucleus with substitution on 2 and 5 position in order to find out their potential as analgesic and anti-inflammatory agents and maybe increase selectivity and reduce adverse effect. Azo compound is prepared by diazotization reaction between 2 amino 5-[(4-methoxy phenyl)-1, 3, 4-thiadiazole and various coupling component to get target product. The purification of compound was done by recrystallization with ethanol and further characterized by spectroscopic technique such as FTIR spectroscopy. Significant biological activity showed of all synthesized compound against carrageenan induced rat paw edema method
Keywords: Non-steroidal anti-inflammatory, 1, 3, 4-Thiadiazole, Anti-inflammatory activity.
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