Romina Christiana Pavlovici, Adriana Vasilache, Stefan-Dimitrie Albu and Cristina-Crenguta Albu*


Mesiodens is a supernumerary tooth located in the premaxilla between the two central incisors that causes a variety of dental problems such as impaired dentofacial aesthetics, malocclusion, dental impaction, and sometimes cyst formation. We are presenting the genetic study performed by the Genetics Department of A.S. Medical Center, in Bucharest, Romania, in the case of a patient presenting a mesiodens in the permanent dentition, an isolated case, non-syndromic and non-hereditary, the result of a de novo mutation. The oral visual examination and the radiological exam of the patient were completed with the oral photographic examination, the family history investigation, the pedigree, and the analysis of the studied family’s genealogical tree, after acquiring the signed informed consent of the patient. The genetic investigations of the mesiodens, allow for the identification of their genetic cause, the calculation of the anomaly recurrence risk amongst offspring, the direct monitoring, and the specialized observation of affected families, to limit the potential complications.

Keywords: mesiodens, non-syndromic, genetic study, genealogic tree, dental anomaly

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