European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW: LIQUISOLID TECHNIQUE

Roshani I. Sheikh*, Dr. Shrikant D. Pande, Pawan B. Tripathi, Jaya P. Madage, Minal S. Taywade and Vivek S. Harbade

ABSTRACT

Slow dissolution rate of poorly water soluble drugs plays a major challenge in the drug development. Drug dissolution and its release from the dosage form have basic impact on bioavailability. Bioavailability depends on solubility of drug. Liquisolid technology is the most latest and novel approach to overcoming the problem of poorly soluble drugs. This technique is an effective method for formulating water insoluble and water soluble drugs. It relies upon the admixture of drug loaded solutions with applicable carrier and coating materials. Liquisolid technique involves a preparation where the liquid drug present in the form of a solution or suspension is converted into a non-sticky, dry, compactable, free-flowing powders, this is accomplished by adding certain coating agents and carriers agents that are appropriate. Liquisolid technique is a promising alternative for formulation of water-insoluble solid drugs and liquid drugs and a novel approach for solubility enhancement.

Keywords: Liquisolid technique, poorly water soluble drug, solubility enhancement, carrier and coating material.