Abstract
FORMULATION AND OPTIMIZATION OF NANOGEL OF DICLOFENAC DIETHYLAMINE FOR TRANSDERMAL DRUG DELIVERY.

Monika Saini* and Dr. R. K. Narang

ABSTRACT

The aim of this study is to formulate nanogel of diclofenac by double emulsification method. The formulations are characterized for the particle size which should be below than 400 nm. .A formulation of nanogel consisting an emulsifier phase of Tefose63, a co-emulsifier Labrafil1944 and Transcutol P was found to be ideal, with mean particle size of 228 nm with a high capacity of solubilisation for diclofenac. The drug entrapment in the formulations was found satisfactory. The optimization of nanogel was carried out by using factorial design and the formulations are characterized for in vitro drug diffusion, skin permeability, rheological properties and in vivo animal study. The in vivo animal studies showed significant improvement in the activity for the formulation in comparison with the conventional marketed formulation. The formulation showed optimal permeability properties, stability and possessed a sustained drug release during the study period. The nanogel formulation showed the promising alternative to oral administration for diclofenac diethylamine.

Keywords: nanogel, Labrafil1944 and Transcutol P .


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