MULTIPARTICULATES DRUG DELIVERY SYSTEM: A REVIEW
Akshay Karbhari Jadhav*, Ankita Sahebrao Jadhav, Mukund Annasaheb Kere and Pratik Deepak Ahire
ABSTRACT
Pharmaceutical invention and research are increasingly focusing on delivery systems which enhance desirable
therapeutic objectives while minimising side effects. Recent trends indicate that Multiparticulate drug delivery
systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose
dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric
residence time. The release of drug from microparticles depends on a variety of factors including the carrier used
to form the multiparticles and the amount of drug contained in them. Consequently, multiparticulate drug delivery
systems provide tremendous opportunities for designing new controlled and delayed release oral formulations,
thus extending the frontier of future pharmaceutical development. Multi-particulate drug delivery systems are
mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some desired. In these
systems, the dosage of the drug substances is divided on a plurality of subunit, typically consisting of thousands of
spherical particles with diameter of 0.05- 2.00mm.
Keywords: Multiparticulate drug delivery system, pellets, palletisation techniques, Melt extrusion, Mini tablet, Natural, Extrusion Spheronization
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