DEVELOPMENTAND VALIDATION OF FIRST ORDER DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF TELMISARTAN, METOPROLOL SUCCINATE AND CHLORTHALIDONE IN BULK AND TABLET DOSAGE FORM.
S. Tamizhselvi* and Dr. T. Sudha
ABSTRACT
A simple, sensitive, rapid, economic and accurate first order derivative spectrophotometric method has been developed for estimation of Telmisartan (TMS), Metoprolol succinate (MPS) and Chlorthalidone (CTD) and in bulk and in tablet dosage form. The wavelengths selected for quantitation were 315 nm for TMS (zero cross for Metoprolol succinate and Chlorthalidone), 231 nm for Metoprolol succinate (No zero cross for Telmisartan and Chlorthalidone) and 250 nm for Chlorthalidone (zero cross for Telmisartan and Metoprolol succinate). Beer’s law was obeyed in the concentration range of 16-80 μg/ml, 9.5- 47.5 μg/ml and 2-12.4 μg/ml for TMS, MPS and CTD. The methods were validated as per ICH guidelines. Statistical analysis proved that the methods were accurate, precise, and reproducible for analysis of TMS, MPS and CTD in tablet dosage form. The wide linearity range, sensitivity, accuracy and simple procedure imply that the proposed technique demonstrated to be appropriate for routine analysis and quality control assay of tablet.
Keywords: Telmisartan, Metoprolol succinate, Chlorthalidone, First Order Derivative Spectroscopy
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